Your family is likely familiar with how hard it is to control seizures associated with CDKL5 deficiency disorder (CDD). Your child may have tried several seizure medicines or may be on multiple medicines and still experiencing frequent seizures.
Seizures can disrupt daily life. They may cause your child to miss school, therapy, and other activities. Seizures can affect your family's balance of good days with CDD—the days with fewer seizures when you can interact more easily with your child or complete a therapy session.
Talk to your healthcare provider about the opportunity to reduce your child’s seizures and what more “good days” could mean for your family. You can use the Doctor Discussion Guide to start the conversation about whether it is time to make a change.
Download the Doctor Discussion Guide
CDD is a rare disease that occurs in approximately 1 in 40,000 births
Seizures begin in infancy and typically continue throughout life
Seizures can occur daily in most people with CDD and are often severe
People with CDD experience delays in physical and mental abilities
Sleepiness: ZTALMY may cause sleepiness. Taking ZTALMY with central nervous system (CNS) depressants including alcohol may increase sleepiness. Do not drive, operate heavy machinery, or do other dangerous activities until you know how ZTALMY affects you or your child.
ZTALMY can cause serious side effects, including:
Sleepiness: ZTALMY may cause sleepiness. Taking ZTALMY with central nervous system (CNS) depressants including alcohol may increase sleepiness. Do not drive, operate heavy machinery, or do other dangerous activities until you know how ZTALMY affects you or your child.
Suicidal Thoughts or Actions: Like all other antiepileptic drugs, ZTALMY may cause suicidal thoughts or actions in a very small number of people, about 1 in 500. Call your healthcare provider right away if you or your child have any of these symptoms, especially if they are new, worse, or worry you:
Pay attention to changes, especially sudden changes in mood, behaviors, thoughts, or feelings. Keep all follow-up visits with your healthcare provider as scheduled.
Stopping ZTALMY: Do not stop taking ZTALMY without first talking to your healthcare provider. Stopping ZTALMY suddenly can cause you or your child to have seizures more often or seizures that do not stop (status epilepticus).
Before taking ZTALMY, tell your healthcare provider about all of your or your child’s medical conditions, including if you or your child:
Tell your healthcare provider about all the medicines you or your child take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. ZTALMY may affect the way other medicines work, and other medicines may affect how ZTALMY works. Do not stop or start taking other medicines without talking to your healthcare provider.
Especially tell your healthcare provider if you or your child take: alcohol; opioids; antidepressants.
Know the medicines you or your child take. Keep a list of them to show your healthcare provider or pharmacist when you or your child get a new medicine.
Do not drive, operate heavy machinery, or do other dangerous activities until you know how ZTALMY affects you or your child. ZTALMY may cause you or your child to feel sleepy.
See "What is the most important information I should know about ZTALMY?"
The most common side effects of ZTALMY include:
These are not all of the possible side effects of ZTALMY. For more information ask your healthcare provider or pharmacist. Tell your healthcare provider about any side effect that bothers you or your child or that does not go away. Call your doctor for medical advice about side effects. You may report side effects to the FDA at www.fda.gov/medwatch or 1-800-FDA-1088. You may also contact Marinus Pharmaceuticals at 844-627-4687.
For additional information, please click here for Medication Guide and Instructions for Use and discuss with your doctor.